Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
نویسندگان
چکیده
منابع مشابه
p53 downregulates the Fanconi anaemia DNA repair pathway
Germline mutations affecting telomere maintenance or DNA repair may, respectively, cause dyskeratosis congenita or Fanconi anaemia, two clinically related bone marrow failure syndromes. Mice expressing p53(Δ31), a mutant p53 lacking the C terminus, model dyskeratosis congenita. Accordingly, the increased p53 activity in p53(Δ31/Δ31) fibroblasts correlated with a decreased expression of 4 genes ...
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ژورنال
عنوان ژورنال: Nature
سال: 2013
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature11863